This case study reports on a 60-year-old female patient with septic shock and MOF after cholecystectomy which was complicated by massive aspiration and necrotizing pancreatitis. On admission to ITU, the patient was in respiratory and acute renal failure and exhibited high needs for vasopressors and fluids. Lung-protective ventilation and hemodynamic stabilization, antibiotic therapy and CRRT plus Cytosorb were started in the further course. During the first 48 h of hemoadsorption, norepinephrine requirements decreased markedly. During the second use of CytoSorb norepinephrine infusion could be stopped after 40 h. CRRT was stopped 11 days after the second CytoSorb treatment and two days later the patient was successfully weaned from ventilation. The authors conclude that they could successfully use intermittent cytokine hemoadsorption to manage a patient with recurrent septic shock, necrotising pancreatitis and MOF. Supplementing the standard treatment for sepsis with two applications of hemoadsorption facilitated rapid hemodynamic stabilization. Cytosorb was easy to use and no adverse effects were observed.