Series Cardiac Surgery

Treatment of post-cardiopulmonary bypass SIRS by hemoadsorption: a case series

Traeger K, Fritzler D, Fischer G, Schröder J, Skrabal C, Liebold A, Reinelt H
Int J Artif Organs 2016; 00(00): 000-000

Objective of thiscase series in 16 adult patients undergoing standard or emergency cardiothoracic surgery procedures...

Objective of thiscase series in 16 adult patients undergoing standard or emergency cardiothoracic surgery procedures with prolonged CPB time, developing post-CPB SIRS over the course of the first post-operative 24 hours was to test the effect of CytoSorb on changes of inflammatory cytokines levels, metabolic parameters hemodynamic variables, and patient outcome. Treatment of these patients with CytoSorb in conjunction with CVVHD was associated with decreases in the proinflammatory cytokines, IL-6 and IL-8, as well as a clear stabilization of hemodynamic, metabolic and organ function parameters. All patients with an APACHE score of up to 30 survived. This is the first case series reporting the use of CytoSorb therapy in patients with post-CPB SIRS. Due to a modulation of the cytokine response, CytoSorb may offer a potentially promising new treatment option for severe post-CPB SIRS that presents with hemodynamic instability and requires high doses of vasopressors.

Systemic Inflammatory Response Syndrome in der Herzchirurgie: Neue Therapiemöglichkeiten durch den Einsatz eines Cytokin-Adsorbers während EKZ?

Born F, Pichlmaier M, Peter S, Khaladj N, Hagl C
Kardiotechnik 2/2014

In this retrospective observational study in 40 patients undergoing a major cardiosurgical procedure with the...

In this retrospective observational study in 40 patients undergoing a major cardiosurgical procedure with the application of a Cardio-Pulmonary-Bypass (CPB) (n=20 withCPB, n=20 with CPBand additionally implemented CytoSorb- adsorber into the circulation) the hypothesis was tested, whether the intraoperative treatment with CytoSorb has a positive effect on the developing post-operative SIRS. Results show, that CytoSorb contributes to a significant reduction of post-operative SIRS in those patients. This study further emphasizes the reliability and safety of CytoSorb also in the settingof cardio surgery.