Monocenter studies

Numerous well-known German and international hospitals are currently performing monocentric scientific studies on the efficacy and clinical effects of the use of CytoSorb in a variety of hyper-inflammatory conditions (e.g. severe sepsis, septic shock, acute pancreatitis, trauma, and consequences of cardiopulmonary bypass in cardiac surgery). Several studies in other application areas such as burn injury or liver failure are in preparation. In total, more than 50 investigator initiated studies are in process, with more than 20 enrolling, 4 having been completed and the rest in various stages of planning.

In the US, the US Air Force is funding a trauma and rhabdomyolysis trial that is currently enrolling under an FDA approved IDE protocol.

Some of these projects are currently close to completion of the clinical phase, so we expect an increase in published evidence on the effectiveness and clinical outcomes of CytoSorb therapy in these applications in the coming months.

As more studies begin enrolling, they will be detailed here. Overview of currently ongoing monocentric studies:

CytoSorbents study ID

Category

Country 

Site

Patient No.

Status

Registration

S20.111-1

Septic shock

Germany

Greifswald University

20

publication phase

link

S20.111-2

Septic shock

Hungary

Szeged University

20

recruiting

link

S40.221-1

Rhabdomyolysis in trauma

US

San Antonio Military Medical Center

30

recruiting

link

S10.111-2

Cardiopulmonary bypass intraoperative

Germany

Hamburg University

40

data analysis

link

S10.111-3

Cardiopulmonary bypass intraoperative

Austria

Vienna University

40

published

link

S10.111-1

Cardiopulmonary bypass intraoperative

Germany

Cologne University

300

recruiting

link

S10.111-5

Cardiopulmonary bypass intraoperative

Germany

Bochum University

40

recruiting

link

S10.111-4

Cardiopulmonary bypass postoperative

Germany

Rostock University

10

recruiting

link

S10.111-7

Cardiopulmonary bypass intraoperative

Germany

Nuremberg hospital

40

in preparation

S50.111-1

Influence on antibiotic/immunosuppressive therapy

Germany

Rostock University, Fraunhofer institute

lab test

inclusion phase

S20.111-3

Septic shock/influence on antibiotic therapy

Germany

Munich University

20

recruiting

S30.111-1

Pancreatitis

Hungary

Debrecen University

24

recruiting

S20.111-5

Septic shock

Germany

Munich Technical University

124

recruiting

link

S20.111-4

Septic shock / influence on antibiotic therapy

Germany

Duesseldorf University

30

recruiting

link

S10.111-10

Cardiopulmonary bypass,  intraoperative

Germany

Duesseldorf University

20

in preparation

S10.111-11

Cardiopulmonary bypass intraoperative

Slovenia

Ljubljana University

60

recruiting

Link

S10.111-9

Cardiopulmonary bypass  postoperative

Germany

Heart Center Dresden

20

recruiting

S10.111-8

Cytokine clearance during cardiopulmonary bypass

Switzerland

Lausanne

15/15

inclusion phase

Link

S50–111.2

Esophageal resection

Germany

UKE Hamburg

12/12

ongoing

Link

S.10.111-12

Cardiopulmonary bypass

Russia

Research Institute for Complex Problems of Cardiovascular diseases, Kemerovo.

100

recruiting

Link