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COVID-19 & CytoSorb Therapy*

COVID-19 can be associated with severe disease, that requires intensive care in approximately 5% of proven infections. The virus can result in a dysregulated immune response and can lead to capillary leak syndrome, progressive lung injury, respiratory failure and acute respiratory distress syndrome (ARDS).

In addition to ARDS, further complications in the critically ill include shock, acute cardiac injury and Acute Kidney Injury (AKI). This is in line with what is known from other viral infections like influenza and previous coronavirus infections (SARS, MERS), as well as with the general fact that infectious and non-infectious triggers can result in a cytokine storm, progressing to vasoplegic shock and finally multi organ dysfunction syndrome.

Rationale of using CytoSorb Therapy in critically ill COVID-19 patients

CytoSorb is a CE marked extracorporeal cytokine adsorber, designed to broadly reduce inflammatory mediators in the blood that could otherwise lead to uncontrolled systemic inflammation, organ failure, and death in many life-threatening illnesses. CytoSorb has been used safely in more than 143,000 treatments worldwide, primarily in the treatment of systemic hyperinflammation in a wide variety of life-threatening conditions.

On 10 April 2020 the US Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) (*) for emergency use of CytoSorb to treat patients 18 years of age or older with confirmed COVID-19 admitted to the ICU with confirmed or imminent respiratory failure by reducing pro-inflammatory cytokine levels.

Experience in Treating Patients with COVID-19 infection

The rationale of using blood purification to help manage the serious complications caused by hyperinflammation in critically ill COVID-19 infected patients, was recently detailed by a recent publication that concluded, “Finally, a sepsis-like syndrome might occur frequently due to the virus itself or to a superimposed bacterial infection and in this case, since pharmacological approaches have shown poor results, new extracorporeal organ support therapies including hemoadsorption and hemoperfusion, with new sorbent cartridges designed to remove cytokines and other circulating mediators, should be considered.” (1)

To date, more than 5,750 critically ill patients with COVID-19 infection have been treated with CytoSorb in 30 countries. The first positive results in Italy have led to the formal recommendation by the Italy Brescia Renal COVID Task Force and published by the Italian Society of Nephrology and ERA-EDTA, to specifically use CytoSorb in severe COVID-19 patients with Stage 3 AKI receiving Continuous Renal Replacement Therapy (CRRT). (2) Also, the recent National Guidelines on adult COVID-19 patients from Panama recommend CytoSorb Therapy, as well as a recently published expert consensus from Colombia. (3,4) In addition, the recent Handbook of COVID-19 Prevention and Treatment from Zhejiang University School of Medicine, China, is also recommending blood purification to treat cytokine storm in critical cases of COVID-19 infection. (5,6) 

CLINICAL ACTIVITIES in
COVID-19 patients

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WHO has assigned a temporary diagnoses code for COVID-19...

LITERATURE

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WHO has assigned a temporary diagnoses code for COVID-19...

Guidelines & Links

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COVID-19 treatment guidelines recommending CytoSorb Therapy​

CODING OF COVID-19 PATIENTS

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WHO has assigned a temporary diagnoses code for COVID-19...

Press Releases

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Webinars

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CLINICAL ACTIVITIES in COVID-19 patients

At CytoSorbents, we are continuously working to build and expand the knowledge surrounding CytoSorb therapy, also in patients with COVID-19. Here we provide an overview of the main clinical activities tailored to generate unbiased scientific evidence.

CytoSorbents conducts its own studies – but since the CytoSorb therapy has been CE approved clinicians have as well been investigating effects of the therapy in investigator-initiated studies. These studies are completely independent from CytoSorbents.

Studies initiated by CytoSorbents:

  • Registry of CytoSorb Therapy in COVID-19 ICU Patients
    Prospective observational study (patient registry)
    Primary Outcome Measure: ICU mortality
    ClinicalTrials.gov

Selected investigator-initiated studies and registries (initiated and run independently from CytoSorbents) that include or focus on CytoSorb treatment in COVID-19 patients:

  • University of Pecs, Hungary
    Data Analysis of the Cytokine Adsorption Treatment on Coronavirus Disease-19 (COVID-19) Patients With Respiratory Failure (CYTOAID)
    Prospective observational cohort
    Primary Outcome Measure: Change in partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio after CytoSorb therapy
    ClinicalTrials.gov

     

  • Brugmann University Hospital Brussels
    Determination of the hemoadsorption impact as adjunctive treatment upon the support therapy of COVID-19
    Pilot randomized control trial
    Primary Outcome Measure: Change in pro and anti-inflammatory cytokine clearances
    ClinicalTrials.gov

  • University of Zurich, Switzerland
    The Risk Stratification in COVID-19 Patients in the ICU Registry (RISC-19-ICU)
    Prospective observational international registry
    Primary Outcome Measure: ICU mortality
    RISC-19-ICU
    ClinicalTrials.gov

  • Jena University Hospital, Germany
    International Registry on the Use of the CytoSorb Adsorber (CytoSorb)
    Prospective observational international registry
    Primary Outcome Measure: Difference between mortality predicted by scoring systems (APACHE II/SAPS II, EuroSCORE II) and actual mortality within 30 days after intervention
    CytoSorb Registry
    ClinicalTrials.gov

  • Charité – Universitätsmedizin Berlin, Germany
    CytoResc – Usage of CytoSorb in COVID-19 associated cytokine storm
    Prospective, randomized, controlled, multi-center pilot study
    Primary Outcome Measure: Time to overcome vasoplegic shock
    German Clinical Trials Registe
    ClinicalTrials.gov

  • University Hospital Freiburg, Germany
    Cytokine Adsorption in Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation (CYCOV)
    Prospective randomized controlled single center study
    Primary Outcome Measure: Interleukin-6 (IL-6) level after 72 hours
    ClinicalTrials.gov

  • University Medical Center Hamburg, Germany
    Effect of CytoSorb Adsorber on Hemodynamic and Immunological Parameters in Critical Ill Patients With COVID-19 (CYTOCOV-19)
    Prospective randomized controlled single center study
    Primary Outcome Measure: Percentage of patients with a significant stabilization of hemodynamics (“shock reversal”) for at least 24 hours
    ClinicalTrials.gov

  • Hospital Clinic of Barcelona, Spain
    Pilot Study on Cytokine Filtration in COVID-19 ARDS (CytokCOVID19)
    Prospective randomized controlled single center study
    Primary Outcome Measure: Mechanical ventilation-free days
    ClinicalTrials.gov

Literature

Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID-19
Biever P, Staudacher DL, Sommer MJ, Triebel H, Neukamm MA, Bode C, Supady A, Lother A.
Pharmacol Res Perspect 2021; 9(2): e00743
CytoSorb Literature Database

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
Tang Y, Liu J, Zhang D, Xu Z, Ji J, Wen C.
Frontiers in Immunology 2020; 11: 1708
CytoSorb Literature Database

Weathering the Cytokine Storm in COVID-19: Therapeutic Implications
Iannaccone G, Scacciavillani R, Del Buono MG, Camilli M, Ronco C, Lavie CJ,  Abbate A, Crea F, Massetti M, Aspromonte N.
Cardiorenal Med 2020: 10(5); 277 – 87
CytoSorb Literature Database

The trinity of COVID-19: immunity, inflammation and intervention
Tay MZ, Poh CM, Renia L, MacAry PA, Ng LFP.
Nat Rev Immunol 2020; 20(6): 363-374
CytoSorb Literature Database

  • Extracorporeal Hemoadsorption: An option for COVID-19 associated Cytokine Storm syndrome
    Napp C, Bauersachs J.
    Shock 2020; 54(5): 700 – 1
    CytoSorb Literature Database

Case of the week 32/2021
Use of CytoSorb in the treatment of a COVID-19 patient with severe ARDS
Dr. Sachin Gupta | Narayana Super Speciality Hospital, Gurgaon, India
CytoSorb Literature Database

Case of the week 24/2021
Use of CytoSorb in a patient with severe COVID-19 pneumonia with bacterial superinfection and septic shock
Dr. med. Dominik Scharpf

Department for Internal Medicine I – Cardiology, Angiology, Pneumology, Internal Intensive Care Medicine, SLK-Kliniken Heilbronn GmbH, Germany
CytoSorb Literature Database

Case of the week 23/2021
Use of CytoSorb in a patient with COVID-19 and acute hypoxic respiratory failure
Daniel Wastl
Medical Clinic – Intensive Care Unit, Krankenhaus Nordwest GmbH, Germany

CytoSorb Literature Database

Case of the week 21/2021
Use of CytoSorb in a patient with severe ARDS and COVID-19 pneumonia
Dr. med. Martin Schmölz

Department of Anesthesia, Intensive Care and Emergency Medicine, Immenstadt Hospital – Klinikverbund Allgäu gGmbH, Germany
CytoSorb Literature Database

Case of the week 18/2021
Use of CytoSorb hemadsorption in a patient with COVID-19 pneumonia and severe ARDS
Dr. Rahul Sharma

Le Crest Hospital, Ghaziabad, India
CytoSorb Literature Database

Case of the week 17/2021
Treatment of a patient with pronounced cytokine storm in severe COVID-19 pneumonia using hemoadsorption in combination with the administration of tocilizumab. A case report
Frank W. Kornitzky1, Heinz-Jakob Langen2, Matthias Held1 | 1 Klinikum Würzburg Mitte gGmbH, Missioklinik, Medical Department with focus on Pneumology & Respiratory Medicine | 2Klinikum Würzburg Mitte gGmbH, Missioklinik, Institute of Radiology | Pneumologie 2021; epub
CytoSorb Literature Database

Case of the week 14/2021
Use of CytoSorb in septic multiple organ failure following intestinal ischemia due to volvulus with concomitant liver failure after COVID-19 disease
Dr. Klaus Kogelmann
CytoSorb Literature Database

Case of the week 12/2021
Use of CytoSorb in a patient with bacterial septic shock and cytokine storm in the context of COVID-19 pneumonia – with a paragraph on the relevance from a nursing perspective
Dr. Benjamin Weber, Dominic Traxler | Clinical Department of Anesthesiology and Intensive Care Medicine, University Hospital St. Pölten – Lilienfeld, Austria

CytoSorb Literature Database

Case of the week 07/2021
Use of CytoSorb in the treatment of severe ARDS in the course of suspected SARS-CoV-2 infection
Rybalko АS, Kiryanova AN, Karpun NA, Chaus NI
CytoSorb Literature Database

Case of the week 06/2021
Use of CytoSorb in a pediatric patient with severe rhabdomyolysis in the context of a SARS-CoV-2 infection
Dr. Raphael Ulreich | Department of Pediatrics and Adolescent Medicine, University Hospital Graz, Graz, Austria

CytoSorb Literature Database

Case of the week 03/2021
Use of CytoSorb in a patient with severe ARDS following COVID-19 pneumonia
Dr. Friedrich Nestler, Dr. Anke Steiner  | Department for Anesthesia and Intensive Care, Erlabrunn Hospital, Germany
CytoSorb Literature Database

Case of the week 51/2020
Use of CytoSorb in a patient with COVID-19-related vasoplegic shock
Dr. Bernd Kurz  | Lung Clinic Neustadt, Department of Pulmonology and Intensive Care Medicine, Neustadt/Harz, Germany

CytoSorb Literature Database

Case of the week 46/2020
Cytokine Hemoadsorption in the Management of a Pregnant Woman with COVID-19 Pneumonia: Case Report.
Karabulut Keklik ES1, Dal H1, Bozok Ş2
1 Department of Anesthesiology and Reanimation, Uşak Training and Research Hospital, Uşak, Turkey
2 Department of Cardiovascular Surgery, Uşak University, Faculty of Medicine, Uşak, Turkey
SN Comprehensive Clinical Medicine 2020; epub
CytoSorb Literature Database 

Case of the week 44/2020
Cytokine adsorption in a patient with severe coronavirus disease 2019 related acute respiratory distress syndrome requiring extracorporeal membrane oxygenation therapy: A case report
Marina Rieder, Timm Zahn, Christoph Benk, Achim Lother, Christoph Bode, Dawid Staudacher, Daniel Duerschmied, Alexander Supady
University of Freiburg, Freiburg, Germany, University of Heidelberg, Heidelberg, Germany
Artif Organs 2020; epub
CytoSorb Literature Database

Case of the week 43/2020
CytoSorb in a critically ill SARS-CoV-2 positive patient with multiple organ failure
Dr. Grzegorz Kieroński and Dr. Wojciech Serednicki | Department of Anesthesiology and Intensive Care, Jagiellonian University Collegium Medicum, Krakow, Poland
CytoSorb Literature Database

Case of the week 42/2020
Use of CytoSorb in a patient with severe COVID-19
Cesar Mercado1, Emilio Rey2, Jorge Rico3, Rodrigo Daza4, Nehomar Pájaro5, Greisy González1, Jaime Gómez1  
1Colombian Association of Nephrology, Bucaramanga, Colombia  | 2Hospital Universitario La Samaritana, Bogotá, Colombia  | 3Colombian Association of Nephrology Medellin, Colombia | 4Colombian Association of Nephrology Cartagena, Colombia | 5
Department of Internal Medicine, University of Sinu, Cartagena, Colombia

CytoSorb Literature Database

Case of the week 39/2020
Use of CytoSorb in a COVID-19-infected patient with urolithiasis
Dr. Antoni Okniński | Department for Anesthesiology and Intensive Care Medicine, Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
CytoSorb Literature Database

Case of the week 38/2020
Use of CytoSorb in a patient with severe ARDS following COVID-19 pneumonia
Dirk Buchwald (1), Roland Köditz (2), Justus Strauch (1) | Department of Cardiac Surgery and Thoracic Surgery (1)
Medical Clinic I, General Internal Medicine (2)
BG University Hospital Bergmannsheil gGmbH, Germany
CytoSorb Literature Database

Case of the week 37/2020
CytoSorb in a patient with severe respiratory failure caused by SARS-CoV-2 Infection
Dr. Wojciech Serednicki and Dr. Grzegorz Kieroński
Department of Anesthesiology and Intensive Care, Jagiellonian University Collegium Medicum, Krakow, Poland
CytoSorb Literature Database 

Case of the week: 27 / 2020
Use of CytoSorb in severe ARDS due to corona virus infection
PD Dr. med. Stephan Ziegeler, Department for Anesthesiology, Operative Intensive Care Medicine, Pain Therapy, Emergency Medicine, Ibbenbüren Hospital, Germany
CytoSorb Literature Database

Case of the Week: 26 / 2020
Use of CytoSorb in a COVID-19-positive patient with severe ARDS
Dr. Antoni Okniński Department for Anesthesiology and Intensive Care Medicine, Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
CytoSorb Literature Database

Case of the Week: 25 / 2020
Use of CytoSorb in a multi-morbidity patient with ARDS in the context of a COVID-19 infection
Dr. Holger Fey, Department for Internal Intensive Care Medicine, Fürth Hospital, Germany
CytoSorb Literature Database

Case of the Week: 24 / 2020
Use of CytoSorb in COVID-19 pneumonia with accompanying bacterial superinfection
Dr. Florian Wunderlich-Sperl, St. Pölten, Austria
CytoSorb Literature Database

Case of the Week: 22 / 2020
Use of CytoSorb in severe ARDS after COVID-19 infection
Dr. Alexander Vogt, University Hospital Halle (Saale), Germany
CytoSorb Literature Database

Case of the Week: 21 / 2020
Use of CytoSorb in a patient with severe ARDS following COVID-19 infection
Dr. Manuel Garcia Montesinos and Dr. Angel Orera Pérez, Navarra, Spain
CytoSorb Literature Database

Case of the Week: 23 / 2020
Use of CytoSorb in combination with ECMO and CVVHD in a patient with ARDS and SARS-CoV2 infection
Shekhar Saha, Dietmar Wassilowsky, Sven Peterss, Christian Hagl, Dominik Joskowiak, Munich, Germany
CytoSorb Literature Database

Efficacy of CytoSorb in a Pediatric Case of Severe Multisystem Inflammatory Syndrome (MIS-C): A Clinical Case Report
Bottari G, Confalone V, Cotugno N, Guzzo I, Perdichizzi S, Manno EC, Stoppa F, Cecchetti C.
Frontiers in Pediatrics 2021; 9: 676298
CytoSorb Literature Database

Successful Treatment of Suspected Donor-derived Human Herpesvirus-8 Infection in a Liver Transplant Patient With Coronavirus Disease-19
Peri AM, Magro B, van den Bogaart L, Dalla Pria A, Giuffrida P, Gianatti A, Fabretti F, Maria Barbui A, Tebaldi A, Rizzi M, Fagiuoli AS.
Transplantation 2021; 105(6): e65-e67
CytoSorb Literature Database

Hemadsorption as a Treatment Option for Multisystem Inflammatory Syndrome in Children Associated WithCOVID-19. A Case Report.
Ruiz-Rodríguez JC, Chiscano-Camón L, Palmada C, Ruiz-Sanmartin A, García-de-Acilu M, Plata-Menchaca E, Perurena-Prieto J, Hernandez-Gonzalez M, Pérez-Carrasco M Soler-Palacin P, Ferrer R. 
Frontiers in Immunology 2021; 12: 665824
CytoSorb Literature Database

Successful use of CytoSorb in a Covid-19 patient with secondary septic shock due to a sacral decubitus infection
Pancani F, Pavani R, Quacquarelli A, Feri M.
Int J Artif Organs 2021;epub
CytoSorb Literature Database

Cytosorb treatment in severe COVID-19 cardiac and pulmonary disease
Ciabatti M, Martinese L, Quacquarelli A, Pieroni M, Feri M, Bolognese L.
Eur Heart J Case Rep 2021; 5(4): ytab123
CytoSorb Literature Database

COVID-19 presenting as acute abdomen and sepsis: a rare case-report
Alharthy A, Balhamar A, Faqihi F, Nasim N, Noor A, Alqahtani SA, Memish ZA, Karakitsos D.
New Microbes and New Infections 2020; 38: 100818
CytoSorb Literature Database

Hemoadsorption cartridge and coronavirus disease 2019 infections: A case report and brief literature review 
Melegari G, Bertellini E, Melegari A, Trenti T, Malaguti S, Barbieri A.
Artif Organs 2021; 45(5): E130 – E135
CytoSorb Literature Database

Cytosorb filter: An adjunct for survival in the COVID-19 patient in cytokine storm? a case report.
Rizvi S, Danic M, Silver M, LaBond V
Heart & Lung 2021; 50(1): 44 – 50
CytoSorb Literature Database 

Cytokine Hemoadsorption in the Management of a Pregnant Woman with COVID-19 Pneumonia: Case Report.
Karabulut Keklik ES, Dal H, Bozok Ş
SN Comprehensive Clinical Medicine 2020; epub
CytoSorb Literature Database 

SARS-CoV-2 infection in kidney transplant recipients: experience of the Italian Marche region
Maritati F, Cerutti E., Zuccatosta L, Fiorentini A, Finale C, Ficosecco M, Cristiano F, Capestro A, Balestra E, Taruscia D, Vivarelli M, Donati A, Perna GP, Giacometti A, Tavio M, Onesta M, Di Sante L, Ranghino A.
Transpl Infect Dis 2020: e13377

CytoSorb Literature Database

The Combined Use of Tocilizumab and Hemoadsorption in a Patient with SARS-COV-2-19-Associated Pneumonia: A Case Report
Berlot G, Tomasini A, Roman Pognuz E, Randino A, Chiella F, La Fata C, Piva M,  Amato P, di Maso V, Bianco F, Gerini U, Tomietto P, Trenti T.
Nephron 2020; 114(9): 459 – 62
CytoSorb Literature Database

Extracorporeal Cytokine Hemadsorption in Severe COVID-19 Respiratory Failure
Damiani M, Gandini L, Landi F, Borleri G, Fabretti F, Gritti G, Riva I
Respiratory Medicine 2021; 185(2021): 106477
CytoSorb Literature Database

Continuous hemadsorption with cytokine adsorber for severe COVID-19: A case series of 15 patients
Paisey C, Patvardhan C, Mackay M, Vuylsteke A, Bhagra SK.
Int J Artif Organs 2021; epub
CytoSorb Literature Database

Longitudinal Cytokine Profiling in Severe COVID-19 Patients on ECMO and Haemoadsorption
Lebreton G, Dorgham K, Quentric P, Combes A, Gorochov G, Schmidt M
Am J Respir Crit Care Med 2021; 203(11): 1433 – 5
CytoSorb Literature Database

Continuous renal replacement therapy with the addition of CytoSorb® cartridge in critically ill patients with COVID‐19 plus acute kidney injury: a case‐series
Alharthy A, Faqihi F, Memish ZA, Balhamar A, Nasim N, Shahzad A, Tamim H, Alqahtani SA, Brindley PG, Karakitsos D.
Artificial Organs 2020; 2021; 45(5): E101 – E112
CytoSorb Literature Database

Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 Pneumonia
Rampino T, Gregorini M, Perotti L, Ferrari F, Pattonieri EF, Grignano MA, Valente M, Garrone A, Islam T, Libetta C, , Albertini R, Bruno R, Belliato M
Blood Purification 2020; epub
CytoSorb Literature Database

RCT
Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial
Supady A, Weber E, Rieder M, Lother A, Niklaus T, Zahn T, Frech F, Müller S, Kuhl M, Benk C, Maier S, Trummer G, Flügler A, Krüger K, Sekandarzad A, Stachon P, Zotzmann V, Bode C, Biever PM, Staudacher D, Wengenmayer T, Graf E, Duerschmied D.
The Lancet Respiratory Medicine 2021; epub
CytoSorb Literature Database

RCT – Research Letter including preliminary analysis
Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation
Rieder M, Wengenmayer T, Staudacher D, Duerschmied D, Supady A.
Crit Care 2020; 24(1): 435
CytoSorb Literature Database

Coding of COVID-19 patients

WHO has assigned a temporary diagnoses code for COVID-19 patients.
  • U07.1 COVID-19, virus identified by laboratory test and
  • U07.2 COVID-19, virus not identified
For ICD-10-WHO these are primary codes. For the German Modification ICD-10-GM these are secondary codes:
  • U07.1! COVID-19, virus identified by laboratory test and
  • U07.2! COVID-19, virus not identified
These codes shall be used with immediate effect of relevant cases. Coding of CytoSorb with COVID-19 patients When CytoSorb is being used in COVID-19 patients it is coded and reimbursed as usual. If you need further information, please have a look here.

Webinars

Webinar Recording from March 4, 2021:
CytoSorb Therapy in critically ill COVID-19 patients – actual results and best practice
International Expert Meeting, Intensive Care

Chair:
Prof. Didier Payen, Nice/France

Speakers:
Prof. Didier Payen, Nice/France | Dr. Axel Nierhaus, Hamburg/Germany | Prof. Manu Malbrain, Brussels/Belgium

Webinar Recording from November 19, 2020:
CytoSorb Therapy in the treatment of critically ill COVID-19 patients
Expert Discussion 2020

Chairs:
Prof. Manu Malbrain/Belgium and Prof. Zsolt Molnar/Hungary 

Speakers:
Dr. Axel Nierhaus/Germany  | Dr. Krishna Patil/India | Dr. Andreas Faltlhauser/Germany

Play Video

Webinar Recording from October 29, 2020: 7th International CytoSorb Users’ Meeting

Moderators: Axel Nierhaus, Germany | Giorgio Berlot, Italy | Ahmad Assiri, Iran | Michael Firstenberg, USA | José Ernesto López Almaraz, Mexico

Webinar Recording from October 8, 2020:
Rationale and Practical use of CytoSorb, an Extracorporeal Cytokine Adsorber, with ECMO to Treat Cytokine Storm in Critically-Ill COVID-19 patient

Chair:
Linda Mongero, Vice President, ECLS/ECMO, SpecialtyCare
Luc Puis, Tiny Perfusion Letter

Speakers:
Dr. Phillip Chan, MD, PhD, CEO CytoSorbents Corporation 
Mr. Stefan Sajgo, Ulm University, Ulm Germany

Play Video

Statements made during the presentations are non-binding and cannot replace the therapy decisions of the treating physician, who is in all cases responsible for the development and implementation of an adequate diagnostic and therapeutic plan for each individual patient. The clinical and preclinical data and results obtained with the CytoSorb adsorber are not transferable to other products.

CytoSorb should only be administered by personnel who have been properly trained in administration of extracorporeal therapies.

We are here for you

Let us answer any questions related to CytoSorb Therapy use in COVID-19 patients.

  1. CytoSorb® is approved in the European Union with distribution in 58 countries around the world, as an extracorporeal cytokine adsorber designed to reduce the “cytokine storm” or “cytokine release syndrome” that could otherwise cause massive inflammation, organ failure and death in common critical illnesses.

    On 10 April 2020 CytoSorb has also received FDA Emergency Use Authorization in the United States for use in critically-ill COVID-19 patients with imminent or confirmed respiratory failure, in defined circumstances.
    In the USA:

    • The CytoSorb device has neither been cleared or approved for the indication to treat patients with COVID-19 infection.
    • The CytoSorb device has been authorized by FDA under an Emergency Use Authorization (EUA).
    • The CytoSorb device is authorized only for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of the CytoSorb device undersection 564(b)(1) of the Act, 21 U.S.C. § 360bbb-3(b)(1), unless the authorization is terminated or revoked sooner.
  1. Ronco C, Navalesi P, Vincent JL. Coronavirus epidemic: preparing for extracorporeal organ support in intensive care. Lancet Resp Med 2020;8(3):240-241.
  2. Brescia Renal Covid Task Force : Alberici F et al., GESTIONE DEL PAZIENTE IN DIALISI E CON TRAPIANTO DI RENE IN CORSO DI INFEZIONE DA CORONAVIRUS COVID-19, published March 18th by the Italian Society of Nephrology and by ERA-EDTA
  3. Asociación Panameña de Medicina Critica y Terapia Intensiva, GUÍAS NACIONALES DE ATENCIÓN DE PACIENTES ADULTOS COVID-19 VERSION 2.0, published on March 22nd
  4. Consenso colombiano de expertos sobre recomendaciones informadas en la evidencia para la prevención, diagnóstico y manejo de la lesión renal aguda por SARS- CoV-2/COVID-19, Revista Colombiana de Nefrología Publicación anticipada en línea, Versión en línea 2500-5006
  5. Liang T (editor-in-Chief). Handbook of COVID-19 Prevention and Treatment, The First Affiliated Hospital, Zhejiang University School of Medicine, Compiled According to Clinical Experience. 
  6. China National Health Commission.  Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th Edition)
  7. Rieder M et al. Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation, Critical Care (2020) 24:435
  8. Berlot G et al. The Combined Use of Tocilizumab and Hemoadsorption in a Patient with SARS-COV-2- 19-Associated Pneumonia: A Case Report, Nephron 2020, epub
  9. Maritati F et al. SARS-CoV-2 INFECTION IN KIDNEY TRANSPLANT RECIPIENTS: EXPERIENCE OF THE ITALIAN MARCHE REGION, TID 2020, epub