Monocenter studies
Numerous renowned German and international clinics are currently conducting monocentric scientific studies on the efficacy and clinical effects of CytoSorb use in a wide range of hyperinflammatory conditions.
Research includes, for e.g. the use of CytoSorb in COVID-19 patients,, intraoperative use in high risk cardiac surgery patients on cardiopulmonary bypass, septic shock or severe acute pancreatitis. Several studies in other applications such as burns or liver failure are in the pipeline. There are many investigator-initiated trials in progress, some of which are already actively recruiting and others which are already completed (see CytoSorb Literature Database for more details). The remaining studies are at different stages of preparation and implementation.
Some of these projects are currently nearing completion or have already been completed, therefore we expect to continue to see a significant increase in published evidence on the effectiveness and clinical outcomes of CytoSorb therapy.
Example of some of the currently running monocenter study projects:
CytoSorbents study ID | Category | Country | Site | Patient No. | Status | Registration |
|---|---|---|---|---|---|---|
S12 | Septic shock | Germany | Munich Technical University | 124 | Recruiting | Link |
CSI03 | Cardiopulmonary bypass intraoperative | Germany | Cologne University | 300 | Data analysis | Link |
CSI06 | Cardiopulmonary bypass intraoperative | Germany | Nuremberg hospital | 40 | Recruiting | Link |
CSI11 | Cardiopulmonary bypass | Russia | Research Institute for Complex Problems of Cardiovascular diseases, Kemerovo. | 100 | Data Analysis | Link |
Tx04 | Orthotopic Heart Transplantation | Hungary | Semmelweis University, Budapest | 60 | Recruiting | Link |
CGS01 | Post arrest | Switzerland | Centre Hospitaliser Universitaire, Vaudois, Lausanne | 40 | Recruiting | Link |
EC05 | Post arrest requiring eCPR | Germany | Freiburg University Hospital, Freiburg | 20 | Data Analysis | Link |
EC03 | Reanimation and ECMO | Germany | Hamburg University Hospital Hamburg – Eppendorf, Hamburg | 40 | Recruiting | Link |
S19 | Septic Shock | Germany | Hamburg University Hospital
Hamburg-Eppendorf, Hamburg | 32 | Recruiting | Link |
CRS | Cytokine Release Syndrome | Germany | Hannover Medical School | 34 | Waiting to recruit | Link |
B03 | Burns | Hungary | University of Pecs | 20 | Waiting to recruit | Link |
IMHeS | Cardiac Surgery | Italy | AOU Mater Domini, Catanzaro | 40 | Waiting to recruit | Link |
Cyto-HOPE | Liver Transplant | Italy | Papa Giovanni XXIII Hospital, Bergamo | 20 | Waiting to recruit | Link |
CSI22 | Cardiac Surgery | Sweden | Sahlgrenska University Hospital
Gothenburg | 20 | Recruiting | Link |
CSI16 | Cardiac Surgery | Switzerland | Dept of Intensive Care Medicine, Bern | 54 | Recruiting | Link |
NEUROCOMB | Septic Shock | Russia | Federal State Autonomous Institution, Burdenko | 14 | Recruiting | Link |
SepsAR3 | Septic Shock | Germany | University Medical Centre, Mainz | 150 | Recruiting | Link |
CYCOV | COVID-19 patients | Germany | Freiburg University Hospital | 30 | Recruiting | Link |
CYTOCOV-19 | COVID-19 patients | Germany | Hamburg University Hospital
Hamburg – Eppendorf, Hamburg | 24 | Recruiting | Link |
O921 | COVID-19 | Belgium | CHU Brugmann, Brussels | 24 | Recruiting | Link |
Sep | Sepsis | Romania | Fundeni Clinical Institute, Bucharest | 100 | Recruiting | Link |
LD | Liver Dysfunction | Romania | Fundeni Clinical Institute, Bucharest | 100 | Recruiting | Link |
S21 | Septic Shock | Netherlands | Nijmegen Radboud UMC | 24 | Recruiting | Link |