Monocenter studies

    Numerous renowned German and international clinics are currently conducting scientific studies on the efficacy and clinical effects of CytoSorb use in a wide range of hyperinflammatory conditions.

    Research includes, for e.g. the use of CytoSorb in COVID-19 patients, intraoperative use in high risk cardiac surgery patients on cardiopulmonary bypass, septic shock or severe acute pancreatitis. Several studies in other clinical conditions where CytoSorb therapy* could be beneficial, such as burns  burns or liver failure are in the pipeline. There are many investigator-initiated trials in progress, some of which are already actively recruiting and others which are already completed (see CytoSorb Literature Database for more details). The remaining studies are at different stages of preparation and implementation.

    Some of these projects are currently nearing completion or have already been completed, therefore we expect to continue to see a significant increase in published evidence on the effectiveness and clinical outcomes of CytoSorb therapy.

    Example of some of the currently running study projects:

    CytoSorbents
    study ID
    Category
    Country
    Site
    Patient No.
    Status
    Registration
    S12
    Septic shock
    Germany
    Munich Technical University
    124
    Recruiting
    Link
    CSI03
    Cardiopulmonary bypass intraoperative
    Germany
    Cologne University
    300
    Data analysis
    Link
    CSI06
    Cardiopulmonary bypass intraoperative
    Germany
    Nuremberg hospital
    40
    Data analysis
    Link
    CSI11
    Cardiopulmonary bypass
    Russia
    Research Institute for Complex Problems of Cardiovascular diseases, Kemerovo.
    100
    Publication phase
    Link
    Tx04
    Orthotopic Heart Transplantation
    Hungary
    Semmelweis University, Budapest
    60
    Recruiting
    Link
    CGS01
    Post arrest
    Switzerland
    Centre Hospitaliser Universitaire, Vaudois, Lausanne
    40
    Recruiting
    Link
    EC05
    Post arrest requiring eCPR
    Germany
    Freiburg University Hospital, Freiburg
    20
    Data analysis
    Link
    EC03
    Reanimation and ECMO
    Germany
    Hamburg University Hospital Hamburg – Eppendorf, Hamburg
    40
    Recruiting
    Link
    S19
    Septic Shock
    Germany
    Hamburg University Hospital Hamburg-Eppendorf, Hamburg
    32
    Recruiting
    Link
    CRS
    Cytokine Release Syndrome
    Germany
    Hannover Medical School
    34
    Recruiting
    Link
    IMHeS
    Cardiac Surgery
    Italy
    AOU Mater Domini, Catanzaro
    40
    Waiting to recruit
    Link
    Cyto-HOPE
    Liver Transplant
    Italy
    Papa Giovanni XXIII Hospital, Bergamo
    20
    Waiting to recruit
    Link
    CSI22
    Cardiac Surgery
    Sweden
    Sahlgrenska University Hospital Gothenburg
    20
    Publication phase
    Link
    CSI16
    Cardiac Surgery
    Switzerland
    Dept of Intensive Care Medicine, Bern
    54
    Recruiting
    Link
    NEUROCOMB
    Septic Shock
    Russia
    Federal State Autonomous Institution, Burdenko
    14
    Recruiting
    Link
    SepsAR3
    Septic Shock
    Germany
    University Medical Centre, Mainz
    150
    Recruiting
    Link
    CYTOCOV-19
    COVID-19 patients
    Germany
    Hamburg University Hospital Hamburg – Eppendorf, Hamburg
    24
    Publication phase
    Link
    O921
    COVID-19
    Belgium
    CHU Brugmann, Brussels
    24
    Data analysis
    Link
    S21
    Septic Shock
    Netherlands
    Nijmegen Radboud UMC
    24
    Recruiting
    Link
    CSI26
    Cardiac Surgery
    Netherlands
    LUMC Leiden
    36
    Waiting to recruit
    Link
    CASAKI
    Septic shock
    Germany
    Munich Technical University
    124
    Recruiting
    Link
    CytoSorb Literature Database
    Literaturliste CytoSorb