Monocenter studies

Numerous renowned German and international clinics are currently conducting monocentric scientific studies on the efficacy and clinical effects of CytoSorb use in a wide range of hyperinflammatory conditions.

Research includes, for e.g. the use of CytoSorb in COVID-19 patients,, intraoperative use in high risk cardiac surgery patients on cardiopulmonary bypass, septic shock or severe acute pancreatitis. Several studies in other applications such as burns or liver failure are in the pipeline. There are many investigator-initiated trials in progress, some of which are already actively recruiting and others which are already completed (see CytoSorb Literature Database for more details). The remaining studies are at different stages of preparation and implementation.

Some of these projects are currently nearing completion or have already been completed, therefore we expect to continue to see a significant increase in published evidence on the effectiveness and clinical outcomes of CytoSorb therapy.

Example of some of the currently running monocenter study projects:

CytoSorbents study ID	Category	Country	Site	Patient No.	Status	Registration
S08	Septic shock	Germany	Greifswald University	20	Published	Link
S07	Septic shock	Hungary	Szeged University	20	Published	Link
S12	Septic shock	Germany	Munich Technical University	124	Recruiting	Link
CSI04	Cardiopulmonary bypass intraoperative	Germany	Hamburg University	40	Published	Link
S10.111-3	Cardiopulmonary bypass intraoperative	Austria	Vienna University	40	Published	Link
CSI03	Cardiopulmonary bypass intraoperative	Germany	Cologne University	300	Data analysis	Link
CSI02	Cardiopulmonary bypass intraoperative	Germany	Bochum University	40	Data Analysis	./.
CSI06	Cardiopulmonary bypass intraoperative	Germany	Nuremberg hospital	40	Recruiting	Link
PCIV03	Influence on antibiotic/immunosuppressive therapy	Germany	Rostock University, Fraunhofer institute	lab test	Publication phase	./.
S15	Septic shock/influence on antibiotic therapy	Germany	Munich University	20	Recruiting	./.
CSI10	Cardiopulmonary bypass intraoperative	Slovenia	Ljubljana University	60	Published	Link
CSI07	Cytokine clearance during cardiopulmonary bypass	Switzerland	Lausanne	15/15	Published	Link
CSI11	Cardiopulmonary bypass	Russia	Research Institute for Complex Problems of Cardiovascular diseases, Kemerovo.	100	Data Analysis	Link
Tx04	Orthotopic Heart Transplantation	Hungary	Semmelweis University, Budapest	60	Recruiting	Link
CGS01	Post arrest	Switzerland	Centre Hospitaliser Universitaire, Vaudois, Lausanne	40	Recruiting	Link
CGS02	Post arrest requiring eCPR	Germany	Freiburg University Hospital, Freiburg	20	Recruiting	Link
EC03	Reanimation and ECMO	Germany	Hamburg University Hospital Hamburg – Eppendorf, Hamburg	40	Recruiting	Link
S19	Septic Shock	Germany	Hamburg University Hospital Hamburg-Eppendorf, Hamburg	32	Recruiting	Link
CRS	Cytokine Release Syndrome	Germany	Hannover Medical School	34	Waiting to recruit	Link
B03	Burns	Hungary	University of Pecs	20	Waiting to recruit	Link
IMHeS	Cardiac Surgery	Italy	AOU Mater Domini, Catanzaro	40	Waiting to recruit	Link
Cyto-HOPE	Liver Transplant	Italy	Papa Giovanni XXIII Hospital, Bergamo	20	Waiting to recruit	Link
CSI22	Cardiac Surgery	Sweden	Sahlgrenska University Hospital Gothenburg	20	Recruiting	Link
CSI16	Cardiac Surgery	Switzerland	Dept of Intensive Care Medicine, Bern	54	Recruiting	Link
NEUROCOMB	Septic Shock	Russia	Federal State Autonomous Institution, Burdenko	14	Recruiting	Link
SepsAR3	Septic Shock	Germany	University Medical Centre, Mainz	150	Recruiting	Link
CYCOV	COVID-19 patients	Germany	Freiburg University Hospital	30	Recruiting	Link
CYTOCOV-19	COVID-19 patients	Germany	Hamburg University Hospital Hamburg – Eppendorf, Hamburg	24	Recruiting	Link
O912	COVID-19	Belgium	CHU Brugmann, Brussels	24	Recruiting	Link
Sep	Sepsis	Romania	Fundeni Clinical Institute, Bucharest	100	Recruiting	Link
LD	Liver Dysfunction	Romania	Fundeni Clinical Institute, Bucharest	100	Recruiting	Link

Newsletter

CytoSorb-Registry

CytoSorb Literature Database