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Monocenter studies

Numerous renowned German and international clinics are currently conducting monocentric scientific studies on the efficacy and clinical effects of CytoSorb use in a wide range of hyperinflammatory conditions.

Research includes, for e.g. the use of CytoSorb in COVID-19 patients,, intraoperative use in high risk cardiac surgery patients on cardiopulmonary bypass, septic shock or severe acute pancreatitis. Several studies in other applications such as burns or liver failure are in the pipeline. There are many investigator-initiated trials in progress, some of which are already actively recruiting and others which are already completed (see CytoSorb Literature Database for more details). The remaining studies are at different stages of preparation and implementation.

Some of these projects are currently nearing completion or have already been completed, therefore we expect to continue to see a significant increase in published evidence on the effectiveness and clinical outcomes of CytoSorb therapy.

Example of some of the currently running monocenter study projects:

CytoSorbents
study ID
Category
Country
Site
Patient No.
Status
Registration
S08
Septic shock
Germany
Greifswald University
20
Published
Link
S07
Septic shock
Hungary
Szeged University
20
Published
Link
S12
Septic shock
Germany
Munich Technical University
128
Recruiting
Link
CSI04
Cardiopulmonary bypass intraoperative
Germany
Hamburg University
40
Published
Link
S10.111-3
Cardiopulmonary bypass intraoperative
Austria
Vienna University
40
Published
Link
CI03
Cardiopulmonary bypass intraoperative
Germany
Cologne University
300
Data analysis
Link
CSI02
Cardiopulmonary bypass intraoperative
Germany
Bochum University
40
Data Analysis
./.
CSI06
Cardiopulmonary bypass intraoperative
Germany
Nuremberg hospital
40
Recruiting
Link
PCIV03
Influence on antibiotic/immunosuppressive therapy
Germany
Rostock University, Fraunhofer institute
lab test
Publication phase
./.
S15
Septic shock/influence on antibiotic therapy
Germany
Munich University
20
Recruiting
./.
CSI10
Cardiopulmonary bypass intraoperative
Slovenia
Ljubljana University
60
Published
Link
CSI07
Cytokine clearance during cardiopulmonary bypass
Switzerland
Lausanne
15/15
Published
Link
CSI11
Cardiopulmonary bypass
Russia
Research Institute for Complex Problems of Cardiovascular diseases, Kemerovo.
100
Data Analysis
Link
Tx04
Orthotopic Heart Transplantation
Hungary
Semmelweis University, Budapest
60
Recruiting
Link
CGS01
Post arrest
Switzerland
Centre Hospitaliser Universitaire, Vaudois, Lausanne
40
Recruiting
Link
CGS02
Post arrest requiring eCPR
Germany
Freiburg University Hospital, Freiburg
20
Recruiting
Link
EC03
Reanimation and ECMO
Germany
Hamburg University Hospital Hamburg – Eppendorf, Hamburg
40
Recruiting
Link
S19
Septic Shock
Germany
Hamburg University Hospital Hamburg-Eppendorf, Hamburg
32
Recruiting
Link
CRS
Cytokine Release Syndrome
Germany
Hannover Medical School
34
Waiting to recruit
Link
B03
Burns
Hungary
University of Pecs
20
Waiting to recruit
Link
IMHeS
Cardiac Surgery
Italy
AOU Mater Domini, Catanzaro
40
Waiting to recruit
Link
Cyto-HOPE
Liver Transplant
Italy
Papa Giovanni XXIII Hospital, Bergamo
20
Waiting to recruit
Link
CSI22
Cardiac Surgery
Sweden
Sahlgrenska University Hospital Gothenburg
20
Recruiting
Link
CSI16
Cardiac Surgery
Switzerland
Dept of Intensive Care Medicine, Bern
54
Recruiting
Link
NEUROCOMB
Septic Shock
Russia
Federal State Autonomous Institution, Burdenko
14
Recruiting
Link
SepsAR3
Septic Shock
Germany
University Medical Centre, Mainz
150
Waiting to recruit
Link
CYCOV
COVID-19 patients
Germany
Freiburg University Hospital
30
Recruiting
Link
CYTOCOV-19
COVID-19 patients
Germany
Hamburg University Hospital Hamburg – Eppendorf, Hamburg
24
Recruiting
Link