Monocenter studies
Numerous renowned German and international clinics are currently conducting scientific studies on the efficacy and clinical effects of CytoSorb use in a wide range of hyperinflammatory conditions.
Research includes, for e.g. the use of CytoSorb in COVID-19 patients, intraoperative use in high risk cardiac surgery patients on cardiopulmonary bypass, septic shock or severe acute pancreatitis. Several studies in other clinical conditions where CytoSorb therapy* could be beneficial, such as burns burns or liver failure are in the pipeline. There are many investigator-initiated trials in progress, some of which are already actively recruiting and others which are already completed (see CytoSorb Literature Database for more details). The remaining studies are at different stages of preparation and implementation.
Some of these projects are currently nearing completion or have already been completed, therefore we expect to continue to see a significant increase in published evidence on the effectiveness and clinical outcomes of CytoSorb therapy.
Example of some of the currently running study projects:
CytoSorbents study ID | Category | Country | Site | Patient No. | Status | Registration |
|---|---|---|---|---|---|---|
CSI03 | Cardiopulmonary bypass intraoperative | Germany | Cologne University | 300 | Data analysis | Link |
CSI06 | Cardiopulmonary bypass intraoperative | Germany | Nuremberg hospital | 40 | Data analysis | Link |
CSI11 | Cardiopulmonary bypass | Russia | Research Institute for Complex Problems of Cardiovascular diseases, Kemerovo. | 100 | Publication phase | Link |
Tx04 | Orthotopic Heart Transplantation | Hungary | Semmelweis University, Budapest | 60 | Recruiting | Link |
CGS01 | Post cardiac arrest | Switzerland | Centre Hospitaliser Universitaire, Vaudois, Lausanne | 40 | Recruiting | Link |
EC05 | Post arrest requiring eCPR | Germany | Freiburg University Hospital, Freiburg | 20 | Publication phase | Link |
EC03 | Reanimation and ECMO | Germany | Hamburg University Hospital Hamburg – Eppendorf, Hamburg | 40 | Recruiting | Link |
S19 | Septic Shock | Germany | Hamburg University Hospital
Hamburg-Eppendorf, Hamburg | 32 | Recruiting | Link |
O03 | Cytokine Release Syndrome | Germany | Hannover Medical School | 34 | Recruiting | Link |
IMHeS | Cardiac Surgery | Italy | AOU Mater Domini, Catanzaro | 40 | Ready for recruitment | Link |
Cyto-HOPE | Liver Transplant | Italy | Papa Giovanni XXIII Hospital, Bergamo | 20 | Ready for recruitment | Link |
CSI22 | Cardiac Surgery | Sweden | Sahlgrenska University Hospital
Gothenburg | 20 | Publication phase | Link |
CSI16 | Cardiac Surgery | Switzerland | Dept of Intensive Care Medicine, Bern | 54 | Recruiting | Link |
NEUROCOMB | Septic Shock | Russia | Federal State Autonomous Institution, Burdenko | 14 | Recruiting | Link |
SepsAR3 | Septic Shock | Germany | University Medical Centre, Mainz | 150 | Recruiting | Link |
CYTOCOV-19 | COVID-19 patients | Germany | Hamburg University Hospital
Hamburg – Eppendorf, Hamburg | 24 | Publication phase | Link |
O921 | COVID-19 | Belgium | CHU Brugmann, Brussels | 24 | Data analysis | Link |
S21 | Septic Shock | Netherlands | Nijmegen Radboud UMC | 24 | Recruiting | Link |
CSI26 | Cardiac Surgery | Netherlands | LUMC Leiden | 36 | Ready for recruitment | Link |